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Welcome to the Rosetta Commons GitHub Organization!

Rosetta Commons drives innovation in biomolecular modeling and design through cutting-edge computational methods and shared software. Our global community of scientists collaborates to advance open, reproducible science and accelerate discovery.

This GitHub organization hosts the tools our community has built – from the original physics-based Rosetta software to the latest ML-driven methods for protein design.

What you'll find here

  • Physics-based tools: The original Rosetta suite for structure prediction, docking, and design
  • ML-based tools: Community-built deep learning methods developed over the past several years
  • Support resources: Documentation and community guidance for every experience level

Getting Started

Not sure where to begin? The Software Download page has an overview of all available repositories with their support levels, so you can find the right tool for your pipeline. For broader context on our organization and mission, visit the Rosetta Commons website.

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  1. rosetta rosetta Public

    The Rosetta Bio-macromolecule modeling package. Available through license with the University of Washington.

    C++ 475 173

  2. PyRosetta.notebooks PyRosetta.notebooks Public

    Jupyter Notebooks for learning the PyRosetta platform for biomolecular structure prediction and design

    Jupyter Notebook 711 173

  3. RFdiffusion RFdiffusion Public

    Code for running RFdiffusion

    Python 3.1k 652

  4. binder binder Public

    Binder, tool for automatic generation of Python bindings

    C++ 369 72

  5. foundry foundry Public

    Central repository for biomolecular foundation models with shared trainers and pipeline components

    Python 994 195

  6. atomworks atomworks Public

    A generalized computational framework for biomolecular modeling.

    Python 452 55

Repositories

Showing 10 of 53 repositories
  • foundry Public

    Central repository for biomolecular foundation models with shared trainers and pipeline components

    RosettaCommons/foundry's past year of commit activity
    Python 994 195 79 (1 issue needs help) 16 Updated Oct 14, 2026
  • RFdiffusion2 Public

    Inference code for RFdiffusion2

    RosettaCommons/RFdiffusion2's past year of commit activity
    Python 447 BSD-3-Clause 71 9 4 Updated Oct 13, 2026
  • rosetta Public

    The Rosetta Bio-macromolecule modeling package. Available through license with the University of Washington.

    RosettaCommons/rosetta's past year of commit activity
    C++ 475 174 26 30 Updated Oct 13, 2026
  • documentation Public

    Documentation for Rosetta Applications. The source for the Rosetta documentation wiki.

    RosettaCommons/documentation's past year of commit activity
    PostScript 10 5 2 15 Updated Oct 12, 2026
  • tmol Public

    TMol - Rosetta on the GPU

    RosettaCommons/tmol's past year of commit activity
    Python 3 BSD-3-Clause 0 0 0 Updated Oct 13, 2026
  • atomworks Public

    A generalized computational framework for biomolecular modeling.

    RosettaCommons/atomworks's past year of commit activity
    Python 452 BSD-3-Clause 55 20 0 Updated Oct 8, 2026
  • HBDesigner Public

    HBDesigner is an algorithm that designs highly-connected hydrogen bonding networks that fit the requested design constraints onto an input protein backbone.

    RosettaCommons/HBDesigner's past year of commit activity
    Python 22 MIT 0 0 0 Updated Oct 2, 2026
  • RFantibody Public
    RosettaCommons/RFantibody's past year of commit activity
    Python 540 MIT 169 77 12 Updated Sep 24, 2026
  • RFDiffusion2_all_the_code Public

    This is all of the code for RFDiffusion2. (i.e. git push from the IPD's current repo)

    RosettaCommons/RFDiffusion2_all_the_code's past year of commit activity
    Python 9 2 0 0 Updated Sep 23, 2026
  • PyRosetta.notebooks Public

    Jupyter Notebooks for learning the PyRosetta platform for biomolecular structure prediction and design

    RosettaCommons/PyRosetta.notebooks's past year of commit activity
    Jupyter Notebook 711 MIT 173 29 6 Updated Sep 19, 2026